Bisphosphonates may double cancer risk
 

Dental News
Article detail

See the following article detail about

Bisphosphonates may double cancer risk

0845 527 9810

Article details for

Bisphosphonates may double cancer risk

 

Bisphosphonates may double cancer risk

People who take oral bisphosphonates for bone disease over five years may be doubling their risk of developing oesophageal cancer, according to a new study published on www.bmj.com today (Friday).

Oral bisphosphonates are a type of drug used to treat osteoporosis and other bone diseases and are the most commonly recommended treatment for such conditions.

Case reports suggest an association between use of oral bisphosphonates for osteoporosis and increased risk of oesophageal cancer.

But the evidence is limited, and no adequately large study with information on potential confounding factors and long follow-up has been published.

So, researchers from the University of Oxford's Cancer Epidemiology Unit and the Medicines and Healthcare products Regulatory Agency carried out a large-scale study to look into the possibility of an association.

They analysed data from the UK General Practice Research Database, which has anonymised patient records for around six million people registered with a NHS GP.

They focused on men and women aged over 40 years – 2,954 with oesophageal cancer, 2,018 with stomach cancer and 10,641 with colorectal cancer diagnosed between 1995 and 2005. Each case was compared with five controls matched for age, sex, general practice and observation period.

They found that people with 10 or more prescriptions, or with prescriptions over about five years, had nearly double the risk of oesophageal cancer compared with people with no bisphosphonate prescriptions.

There was no such increased risk for stomach or bowel cancer.

Typically, oesophageal cancer develops in one per 1000 people at age 60-79 over five years.

Based on their findings, the authors estimate that with five years' use of oral bisphosphonates this would increase to two cases per 1000 people taking bisphosphonates over five years.

Although these results appear to contradict another recently published study using the same database, which reported no increased risk of oesophageal cancer with oral bisphosphonate use, today's report tracked patients for nearly twice as long, and also had greater statistical power.

The study's lead author, Dr Jane Green, says: 'Oesophageal cancer is uncommon. The increased risks we found were in people who used oral bisphosphonates for about five years, and even if our results are confirmed, few people taking bisphosphonates are likely to develop oesophageal cancer as a result of taking these drugs. Our findings are part of a wider picture. Bisphosphonates are being increasingly prescribed to prevent fractures, and what is lacking is reliable information on the benefits and risks of their use in the long term.'

In an accompanying editorial, Dr Diane Wysowski, an epidemiologist at the US Food and Drug Administration, discusses the differences between the two studies.

She says that 'the possibility of adverse effects on the oesophagus should prompt doctors who prescribe these drugs to consider risks versus benefits.'

She also suggests doctors 'tell patients to report difficulty in swallowing and throat, chest, or digestive discomfort so that they can be promptly evaluated and possibly advised to discontinue the drug'.

 Posted on : Fri 3rd - Sep - 2010

 

Call Dental Support UK

Premium IT Support

  • All Servers & workstations covered..
  • Saturday Cover INCLUDED.
  • Telephone support.
  • Remote support.
  • 4 hour on-site Server response.
  • System monitoring.
  • Network monitoring and security.
  • Anti-Virus & Application updates.
  • Unlimited Remote Server Data backup.
  • Loan equipment on hardware failure.
  • Reduced rates for PC parts supply & installations.

No matter how big
your practice you
pay the same
price!!


ONLY

Click here for more info
Dental News Archives 2018

August - 2018
July - 2018
June - 2018
May - 2018
April - 2018
March - 2018
February - 2018
January - 2018

Dental News Archives 2017

December - 2017
November - 2017
October - 2017
September - 2017
August - 2017
July - 2017
June - 2017
May - 2017
April - 2017
March - 2017
February - 2017
January - 2017

Dental News Archives 2016

December - 2016
November - 2016
October - 2016
September - 2016
August - 2016
July - 2016
June - 2016
May - 2016
April - 2016
March - 2016
February - 2016
January - 2016

Dental News Archives 2015

December - 2015
November - 2015
October - 2015
September - 2015
August - 2015
July - 2015
June - 2015
May - 2015
April - 2015
March - 2015
February - 2015
January - 2015

Dental News Archives 2014

December - 2014
November - 2014
October - 2014
September - 2014
August - 2014
July - 2014
June - 2014
May - 2014
April - 2014
March - 2014
February - 2014
January - 2014

Dental News Archives 2013

December - 2013
November - 2013
October - 2013
September - 2013
August - 2013
July - 2013
June - 2013
May - 2013
April - 2013
March - 2013
February - 2013
January - 2013

Dental News Archives 2012

December - 2012
November - 2012
October - 2012
September - 2012
August - 2012
July - 2012
June - 2012
May - 2012
April - 2012
March - 2012
February - 2012
January - 2012

Dental News Archives 2011

January - 2011
February - 2011
March - 2011
April - 2011
May - 2011
June - 2011
July - 2011
August - 2011
September - 2011
October - 2011
November - 2011
December - 2011

Dental News Archives 2010

December - 2010
November - 2010
October - 2010
September - 2010
August - 2010
July - 2010
June - 2010
May - 2010
April - 2010
March - 2010
February - 2010
January - 2010

Dental News Archives 2009

December - 2009
November - 2009
October - 2009
September - 2009
August - 2009
July - 2009
June - 2009
May - 2009
April - 2009
March - 2009
February - 2009
January - 2009

Dental News Archives 2008

December - 2008
November - 2008
October - 2008
September - 2008
August - 2008
July - 2008
June - 2008
May - 2008
April - 2008
March - 2008
February - 2008
January - 2008

Dental News Archives 2007

December - 2007
November - 2007
October - 2007
September - 2007
August - 2007
July - 2007
June - 2007
May - 2007
April - 2007
March - 2007
February - 2007
January - 2007

Dental News Archives 2006

December - 2006
November - 2006
October - 2006
September - 2006
August - 2006
July - 2006
June - 2006
May - 2006
April - 2006
March - 2006
February - 2006
January - 2006

Dental News Archives 2005

December - 2005
November - 2005
October - 2005
September - 2005
August - 2005
July - 2005
June - 2005
May - 2005

hide toolbar
Would you like weekly updates on our latest offers? If so enter your email :
Quick Remote Dental Support